In no particular order, and certainly not a conclusive list, but there are some things that really bother me that I'll call Big Picture Problems:
- Federal Defecit Spending and the growth of the national debt
 - The continued plundering of limited resources and other environmental issues
 - Politicians
 - Overpopulation
 - Nuclear proliferation
 - The continued abatement of freedoms in the name of "security"
 - The ever-increasing power of corporations over people
 - Lack of universal healthcare
 
Accordingly, I'd like to say thanks to the hard-working individuals and organizations who work to improve things, including:
- The ACLU
 - The EFF
 - Greenpeace
 - Citizens Against Government Waste